KEGG   Bos taurus (cow): 3283886
Entry
3283886           CDS       T01008                                 
Symbol
ND4
Name
(RefSeq) NADH dehydrogenase subunit 4
  KO
K03881  NADH-ubiquinone oxidoreductase chain 4 [EC:7.1.1.2]
Organism
bta  Bos taurus (cow)
Pathway
bta00190  Oxidative phosphorylation
bta01100  Metabolic pathways
bta04714  Thermogenesis
bta04723  Retrograde endocannabinoid signaling
bta05010  Alzheimer disease
bta05012  Parkinson disease
bta05014  Amyotrophic lateral sclerosis
bta05016  Huntington disease
bta05020  Prion disease
bta05022  Pathways of neurodegeneration - multiple diseases
bta05208  Chemical carcinogenesis - reactive oxygen species
bta05415  Diabetic cardiomyopathy
Module
bta_M00142  NADH:ubiquinone oxidoreductase, mitochondria
Brite
KEGG Orthology (KO) [BR:bta00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    3283886 (ND4)
 09150 Organismal Systems
  09156 Nervous system
   04723 Retrograde endocannabinoid signaling
    3283886 (ND4)
  09159 Environmental adaptation
   04714 Thermogenesis
    3283886 (ND4)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    3283886 (ND4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3283886 (ND4)
   05012 Parkinson disease
    3283886 (ND4)
   05014 Amyotrophic lateral sclerosis
    3283886 (ND4)
   05016 Huntington disease
    3283886 (ND4)
   05020 Prion disease
    3283886 (ND4)
   05022 Pathways of neurodegeneration - multiple diseases
    3283886 (ND4)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    3283886 (ND4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:bta03029]
    3283886 (ND4)
Enzymes [BR:bta01000]
 7. Translocases
  7.1  Catalysing the translocation of protons
   7.1.1  Linked to oxidoreductase reactions
    7.1.1.2  NADH:ubiquinone reductase (H+-translocating)
     3283886 (ND4)
Mitochondrial biogenesis [BR:bta03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Mitochondrial respiratory chain complex I
    3283886 (ND4)
SSDB
Motif
Pfam: Proton_antipo_M Oxidored_q5_N
Other DBs
NCBI-GeneID: 3283886
NCBI-ProteinID: YP_209214
UniProt: P03910 Q7JAS7
Structure
Position
MT:10529..11906
AA seq 459 aa
MLKYIIPTIMLMPLTWLSKNNMIWVNSTAHSLLISFTSLLLMNQFGDNSLNFSLLFFSDS
LSTPLLILTMWLLPLMLMASQHHLSKENLTRKKLFITMLISLQLFLIMTFTAMELILFYI
LFEATLVPTLIIITRWGNQTERLNAGLYFLFYTLAGSLPLLVALIYIQNTVGSLNFLMLQ
YWVQPVHNSWSNVFMWLACMMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGG
YGMLRITLILNPMTDFMAYPFIMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVA
ILIQTPWSYMGATALMIAHGLTSSMLFCLANSNYERIHSRTMILARGLQTLLPLMATWWL
LASLTNLALPPTINLIGELFVVMSTFSWSNITIILMGVNMVITALYSLYMLIMTQRGKYT
YHINNISPSFTRENALMSLHILPLLLLTLNPKIILGPLY
NT seq 1378 nt   +upstreamnt  +downstreamnt
atgctaaaatacattattccaacaattatacttatacccctaacctggttatcaaaaaat
aatataatttgggttaactccacagcacacagccttctaattagctttacaagcctcctc
ctcataaaccagtttggcgacaacagccttaatttttcactactatttttctccgactcc
ctatccactccactactaattttaaccatatggctcctccctctaatactaatagctagc
caacatcatctatcaaaagaaaacctaacccgaaaaaaactatttattactatgctgatc
tcactacaactattcctaattataacctttaccgccatggaactaatcttattttatatt
ctatttgaagcaacactagtcccaacactcattattattacccgatgaggaaaccaaaca
gaacgcctaaacgccggactctatttcctattctatacactagctggctccctaccccta
ttagtcgcactaatttatatccaaaacacagtaggatccctaaatttcctaatattacag
tactgagtacaacctgttcataactcttgatctaatgtcttcatatgactagcatgtata
atagctttcatagtaaaaataccactatatggcctccacctttgactacctaaagctcac
gtagaagcccccatcgcaggctccatagtccttgcagcagttctgctaaaactagggggg
tacggtatgctacgaatcacactaattctaaaccctatgaccgactttatagcataccca
ttcattatactctccctatgaggcataattataaccagctcaatctgcctccgtcaaacg
gacctaaaatcactcatcgcatactcctctgtaagccacatagcactcgttatcgtagcc
atccttatccagacaccttgaagctacataggagcaaccgcccttatgattgcccacggc
ctcacatcctccatacttttctgtctagcaaactcaaactacgaacgaatccacagccga
accataattctagctcgaggcctacaaacgctccttccactaatagccacctgatgacta
ctagcaagtctaaccaacttagctctacccccaacaatcaacttaattggagaactattt
gtagtaatgtcaaccttttcatgatctaacattacaattattctaataggagtaaatata
gtaatcaccgccctatattctctatacatgctaattataacccaacgaggaaaatatacc
taccacattaataatatctcgccttcctttacacgggaaaatgcactcatatcattacac
atcctacccctactactcctaaccctaaacccaaaaattattctaggacctctatact

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (13)   
   KEGG PATHWAY (12)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
3D Structure (28)   
   PDB (28)   
Protein domain (2)   
   Pfam (2)   
All databases (71)   

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